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Caged circular siRNAs for photomodulation of gene expression in cells and mice

By means of RNA interference (RNAi), small interfering RNAs (siRNAs) play important roles in gene function study and drug development. Recently, photolabile siRNAs were developed to elucidate the process of gene silencing in terms of space, time and degree through chemical modification of siRNAs. We...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Chem Sci
Hauptverfasser: Zhang, Liangliang, Liang, Duanwei, Wang, Yuan, Li, Dong, Zhang, Jinhao, Wu, Li, Feng, Mengke, Yi, Fan, Xu, Luzheng, Lei, Liandi, Du, Quan, Tang, XinJing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869302/
https://ncbi.nlm.nih.gov/pubmed/29629072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc03842a
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