Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice

Circular non-coding RNAs are found to play important roles in biology but are still relatively unexplored as a structural motif for chemically regulating gene function. Here, we investigated whether small interfering RNA (siRNA) with a circular structure can circumvent off-target gene silencing, a p...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Zhang, Liangliang, Liang, Duanwei, Chen, Changmai, Wang, Yuan, Amu, Gubu, Yang, Jiali, Yu, Lijia, Dmochowski, Ivan J., Tang, Xinjing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768153/
https://ncbi.nlm.nih.gov/pubmed/29499936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.12.007
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