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Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics

Stem cells mechanosense the stiffness of their microenvironment, which impacts differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix (ECM) stiffness is clearly transduced into gene expression via adhesion and cytoskeleton proteins that tune fates. Cytoskelet...

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Foilsithe in:Physiology (Bethesda)
Main Authors: Smith, Lucas R., Cho, Sangkyun, Discher, Dennis E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866410/
https://ncbi.nlm.nih.gov/pubmed/29212889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiol.00026.2017
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