Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis

OBJECTIVE: Amyotrophic lateral sclerosis (ALS) clinical trials based on single end points only partially capture the full treatment effect when both function and mortality are affected, and may falsely dismiss efficacious drugs as futile. We aimed to investigate the statistical properties of several...

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Detalhes bibliográficos
Publicado no:Clin Epidemiol
Main Authors: van Eijk, Ruben PA, Eijkemans, Marinus JC, Rizopoulos, Dimitris, van den Berg, Leonard H, Nikolakopoulos, Stavros
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865572/
https://ncbi.nlm.nih.gov/pubmed/29593436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CLEP.S153196
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