Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis

OBJECTIVE: Amyotrophic lateral sclerosis (ALS) clinical trials based on single end points only partially capture the full treatment effect when both function and mortality are affected, and may falsely dismiss efficacious drugs as futile. We aimed to investigate the statistical properties of several...

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Spremljeno u:
Bibliografski detalji
Izdano u:Clin Epidemiol
Glavni autori: van Eijk, Ruben PA, Eijkemans, Marinus JC, Rizopoulos, Dimitris, van den Berg, Leonard H, Nikolakopoulos, Stavros
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2018
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865572/
https://ncbi.nlm.nih.gov/pubmed/29593436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CLEP.S153196
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