Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis

OBJECTIVE: Amyotrophic lateral sclerosis (ALS) clinical trials based on single end points only partially capture the full treatment effect when both function and mortality are affected, and may falsely dismiss efficacious drugs as futile. We aimed to investigate the statistical properties of several...

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Dettagli Bibliografici
Pubblicato in:Clin Epidemiol
Autori principali: van Eijk, Ruben PA, Eijkemans, Marinus JC, Rizopoulos, Dimitris, van den Berg, Leonard H, Nikolakopoulos, Stavros
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2018
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865572/
https://ncbi.nlm.nih.gov/pubmed/29593436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CLEP.S153196
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