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Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis
OBJECTIVE: Amyotrophic lateral sclerosis (ALS) clinical trials based on single end points only partially capture the full treatment effect when both function and mortality are affected, and may falsely dismiss efficacious drugs as futile. We aimed to investigate the statistical properties of several...
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| Vydáno v: | Clin Epidemiol |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Dove Medical Press
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5865572/ https://ncbi.nlm.nih.gov/pubmed/29593436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CLEP.S153196 |
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