Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis

OBJECTIVE: Amyotrophic lateral sclerosis (ALS) clinical trials based on single end points only partially capture the full treatment effect when both function and mortality are affected, and may falsely dismiss efficacious drugs as futile. We aimed to investigate the statistical properties of several...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Epidemiol
Egile Nagusiak: van Eijk, Ruben PA, Eijkemans, Marinus JC, Rizopoulos, Dimitris, van den Berg, Leonard H, Nikolakopoulos, Stavros
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Dove Medical Press 2018
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865572/
https://ncbi.nlm.nih.gov/pubmed/29593436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CLEP.S153196
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