Monitoring disease progression with plasma creatinine in amyotrophic lateral sclerosis clinical trials

OBJECTIVES: Plasma creatinine is a predictor of survival in amyotrophic lateral sclerosis (ALS). It remains, however, to be established whether it can monitor disease progression and serve as surrogate endpoint in clinical trials. METHODS: We used clinical trial data from three cohorts of clinical t...

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Udgivet i:J Neurol Neurosurg Psychiatry
Main Authors: van Eijk, Ruben P A, Eijkemans, Marinus J C, Ferguson, Toby A, Nikolakopoulos, Stavros, Veldink, Jan H, van den Berg, Leonard H
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2018
Fag:
Neuromuscular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800333/
https://ncbi.nlm.nih.gov/pubmed/29084868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2017-317077
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