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Comprehensive computational design of ordered peptide macrocycles
Mixed-chirality peptide macrocycles such as cyclosporine are among the most potent therapeutics identified to date, but there is currently no way to systematically search the structural space spanned by such compounds. Natural proteins do not provide a useful guide: Peptide macrocycles lack regular...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Science |
|---|---|
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5860875/ https://ncbi.nlm.nih.gov/pubmed/29242347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aap7577 |
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