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Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
Despite recent success in computational design of structured cyclic peptides, de novo design of cyclic peptides that bind to any protein functional site remains difficult. To address this challenge, we develop a computational “anchor extension” methodology for targeting protein interfaces by extendi...
Enregistré dans:
| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8185074/ https://ncbi.nlm.nih.gov/pubmed/34099674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23609-8 |
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