Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites

Despite recent success in computational design of structured cyclic peptides, de novo design of cyclic peptides that bind to any protein functional site remains difficult. To address this challenge, we develop a computational “anchor extension” methodology for targeting protein interfaces by extendi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Hosseinzadeh, Parisa, Watson, Paris R., Craven, Timothy W., Li, Xinting, Rettie, Stephen, Pardo-Avila, Fátima, Bera, Asim K., Mulligan, Vikram Khipple, Lu, Peilong, Ford, Alexander S., Weitzner, Brian D., Stewart, Lance J., Moyer, Adam P., Di Piazza, Maddalena, Whalen, Joshua G., Greisen, Per Jr., Christianson, David W., Baker, David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2021
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185074/
https://ncbi.nlm.nih.gov/pubmed/34099674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23609-8
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia