Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites

Despite recent success in computational design of structured cyclic peptides, de novo design of cyclic peptides that bind to any protein functional site remains difficult. To address this challenge, we develop a computational “anchor extension” methodology for targeting protein interfaces by extendi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hosseinzadeh, Parisa, Watson, Paris R., Craven, Timothy W., Li, Xinting, Rettie, Stephen, Pardo-Avila, Fátima, Bera, Asim K., Mulligan, Vikram Khipple, Lu, Peilong, Ford, Alexander S., Weitzner, Brian D., Stewart, Lance J., Moyer, Adam P., Di Piazza, Maddalena, Whalen, Joshua G., Greisen, Per Jr., Christianson, David W., Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185074/
https://ncbi.nlm.nih.gov/pubmed/34099674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23609-8
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