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MHCEpitopeEnergy, a flexible Rosetta-based biotherapeutic deimmunization platform
As non-“self” macromolecules, biotherapeutics can trigger an immune response that can reduce drug efficacy, require patients to be taken off therapy, or even cause life-threatening reactions. To enable flexible and facile design of protein biotherapeutics while reducing the prevalence of T cell epit...
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| Publicado no: | J Chem Inf Model |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8225355/ https://ncbi.nlm.nih.gov/pubmed/33900750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.1c00056 |
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