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Engineering carboxypeptidase G2 circular permutations for the design of an autoinhibited enzyme

Carboxypeptidase G2 (CPG2) is an Food and Drug Administration (FDA)-approved enzyme drug used to treat methotrexate (MTX) toxicity in cancer patients receiving MTX treatment. It has also been used in directed enzyme-prodrug chemotherapy, but this strategy has been hampered by off-site activation of...

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Detalhes bibliográficos
Publicado no:Protein Eng Des Sel
Main Authors: Yachnin, Brahm J., Khare, Sagar D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283397/
https://ncbi.nlm.nih.gov/pubmed/28160000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzx005
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