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Computational Design of a Photo-controlled Cytosine Deaminase
There is growing interest in designing spatiotemporal control over enzyme activities using noninvasive stimuli such as light. Here, we describe a structure-based, computation-guided predictive method for reversibly controlling enzyme activity using covalently attached photo-responsive azobenzene gro...
Gardado en:
| Publicado en: | J Am Chem Soc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6830878/ https://ncbi.nlm.nih.gov/pubmed/29251923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08709 |
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