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Engineering carboxypeptidase G2 circular permutations for the design of an autoinhibited enzyme
Carboxypeptidase G2 (CPG2) is an Food and Drug Administration (FDA)-approved enzyme drug used to treat methotrexate (MTX) toxicity in cancer patients receiving MTX treatment. It has also been used in directed enzyme-prodrug chemotherapy, but this strategy has been hampered by off-site activation of...
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| Udgivet i: | Protein Eng Des Sel |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6283397/ https://ncbi.nlm.nih.gov/pubmed/28160000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzx005 |
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