Computational design of mixed chirality peptide macrocycles with internal symmetry

Cyclic symmetry is frequent in protein and peptide homo‐oligomers, but extremely rare within a single chain, as it is not compatible with free N‐ and C‐termini. Here we describe the computational design of mixed‐chirality peptide macrocycles with rigid structures that feature internal cyclic symmetr...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Mulligan, Vikram Khipple, Kang, Christine S., Sawaya, Michael R., Rettie, Stephen, Li, Xinting, Antselovich, Inna, Craven, Timothy W., Watkins, Andrew M., Labonte, Jason W., DiMaio, Frank, Yeates, Todd O., Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2020
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Full‐Length Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679966/
https://ncbi.nlm.nih.gov/pubmed/33058266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3974
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