Computational design of mixed chirality peptide macrocycles with internal symmetry

Cyclic symmetry is frequent in protein and peptide homo‐oligomers, but extremely rare within a single chain, as it is not compatible with free N‐ and C‐termini. Here we describe the computational design of mixed‐chirality peptide macrocycles with rigid structures that feature internal cyclic symmetr...

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Dettagli Bibliografici
Pubblicato in:Protein Sci
Autori principali: Mulligan, Vikram Khipple, Kang, Christine S., Sawaya, Michael R., Rettie, Stephen, Li, Xinting, Antselovich, Inna, Craven, Timothy W., Watkins, Andrew M., Labonte, Jason W., DiMaio, Frank, Yeates, Todd O., Baker, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2020
Soggetti:
Full‐Length Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679966/
https://ncbi.nlm.nih.gov/pubmed/33058266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3974
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