Dissection of the Role of VIMP in Endoplasmic Reticulum-Associated Degradation of CFTRΔF508

Endoplasmic reticulum (ER)-associated protein degradation (ERAD) is an important quality control mechanism that eliminates misfolded proteins from the ER. The Derlin-1/VCP/VIMP protein complex plays an essential role in ERAD. Although the roles of Derlin-1 and VCP are relatively clear, the functiona...

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Udgivet i:Sci Rep
Main Authors: Hou, Xia, Wei, Hongguang, Rajagopalan, Carthic, Jiang, Hong, Wu, Qingtian, Zaman, Khalequz, Xie, Youming, Sun, Fei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859151/
https://ncbi.nlm.nih.gov/pubmed/29555962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23284-8
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