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Evaluating hydrophobic galactonoamidines as transition state analogs for enzymatic β-galactoside hydrolysis
A spectroscopic examination of six galactonoamidines with inhibition constants and efficacy in the low nanomolar concentration range (K(i) = 6–11 nM, IC(50) =12–36 nM) suggested only two of them as putative transition state analogs for the hydrolysis of β-galactosides by β-galactosidase (A. oryzae)....
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| Publicado no: | Bioorg Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5857253/ https://ncbi.nlm.nih.gov/pubmed/29353731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2018.01.012 |
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