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Picomolar inhibition of β-galactosidase (bovine liver) attributed to loop closure
In an effort to examine similarities in the active sites of glycosidases within the GH35 family, we performed a structure-activity-relationship study using our recently described library of galactonoamidines. The kinetic evaluation based on UV/Vis spectroscopy disclosed inhibition of β-galactosidase...
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| Udgivet i: | Bioorg Med Chem |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5632213/ https://ncbi.nlm.nih.gov/pubmed/28844803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.07.020 |
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