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Investigation of Amide Bond Formation during Dehydrophos Biosynthesis

Dehydrophos is a tripeptide phosphonate antibiotic produced by Streptomyces luridus. Its biosynthetic pathway involves the use of aminoacyl-tRNA (aa-tRNA) for amide bond formation. The first amide bond during biosynthesis is formed by DhpH-C, a peptidyltransferase that utilizes Leu-tRNA(Leu). DhpH-C...

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Bibliografiska uppgifter
I publikationen:ACS Chem Biol
Huvudupphovsmän: Ulrich, Emily C., Bougioukou, Despina J., van der Donk, Wilfred A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856630/
https://ncbi.nlm.nih.gov/pubmed/29303545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00949
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