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Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway
Bioactive natural products containing a C-P bond act as mimics of phosphate esters and carboxylic acids, thereby competing with these compounds for active sites of enzymes. Dehydrophos (DHP), a broad-spectrum antibiotic, is a phosphonotripeptide produced by Streptomyces luridus, in which glycine and...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3704017/ https://ncbi.nlm.nih.gov/pubmed/23776232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303568110 |
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