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Use of the Dehydrophos Biosynthetic Enzymes to Prepare Antimicrobial Analogs of Alaphosphin
The C-terminal domain of the dehydrophos biosynthetic enzyme DhpH (DhpH-C) catalyzes the condensation of Leu-tRNA(Leu) with (R)-1-aminoethylphosphonate, the aminophosphonate analog of alanine called Ala(P). The product of this reaction, Leu-Ala(P), is a phosphonodipeptide, a class of compounds that...
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| 出版年: | Org Biomol Chem |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6344287/ https://ncbi.nlm.nih.gov/pubmed/30608108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob02860e |
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