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Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis

Phosphonate natural products possess a range of biological activities as a consequence of their ability to mimic phosphate esters or tetrahedral intermediates formed in enzymatic reactions involved in carboxyl group metabolism. The dianionic form of these compounds at pH 7 poses a drawback with resp...

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Hlavní autoři: Lee, Jin-Hee, Bae, Brian, Kuemin, Michael, Circello, Benjamin T., Metcalf, William W., Nair, Satish K., van der Donk, Wilfred A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955109/
https://ncbi.nlm.nih.gov/pubmed/20876132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006848107
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