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Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway

Bioactive natural products containing a C-P bond act as mimics of phosphate esters and carboxylic acids, thereby competing with these compounds for active sites of enzymes. Dehydrophos (DHP), a broad-spectrum antibiotic, is a phosphonotripeptide produced by Streptomyces luridus, in which glycine and...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bougioukou, Despina J., Mukherjee, Subha, van der Donk, Wilfred A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704017/
https://ncbi.nlm.nih.gov/pubmed/23776232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303568110
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