The Antibiotic Dehydrophos Is Converted to a Toxic Pyruvate Analog by Peptide Bond Cleavage in Salmonella enterica

The metabolic processing of dehydrophos, a broad-spectrum peptide antibiotic containing an unusual vinyl-phosphonate moiety, was examined by using a panel of Salmonella enterica mutants deficient in peptide uptake and catabolism. Dehydrophos bioactivity is lost in opp tpp double mutants, demonstrati...

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Main Authors: Circello, Benjamin T., Miller, Charles G., Lee, Jin-Hee, van der Donk, Wilfred A., Metcalf, William W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
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Mechanisms of Action: Physiological Effects
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122408/
https://ncbi.nlm.nih.gov/pubmed/21537024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01483-10
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