Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease

Exposure of cultured primary neurons to preformed α-synuclein fibrils (PFFs) leads to the recruitment of endogenous α-synuclein and its templated conversion into fibrillar phosphorylated α-synuclein (pα-synF) aggregates resembling those involved in Parkinson’s disease (PD) pathogenesis. Pα-synF was...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Grassi, Diego, Howard, Shannon, Zhou, Minghai, Diaz-Perez, Natalia, Urban, Nicolai T., Guerrero-Given, Debbie, Kamasawa, Naomi, Volpicelli-Daley, Laura A., LoGrasso, Philip, Lasmézas, Corinne Ida
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856519/
https://ncbi.nlm.nih.gov/pubmed/29487216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713849115
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