The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity

Emerging evidence strongly suggests that chaperone proteins are cytoprotective in neurodegenerative proteinopathies involving protein aggregation; for example, in the accumulation of aggregated α-synuclein into the Lewy bodies present in Parkinson’s disease. Of the various chaperones known to be ass...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Jarvela, Timothy S., Lam, Hoa A., Helwig, Michael, Lorenzen, Nikolai, Otzen, Daniel E., McLean, Pamela J., Maidment, Nigel T., Lindberg, Iris
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987805/
https://ncbi.nlm.nih.gov/pubmed/27457957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601091113
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