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Blockade of Islet Amyloid Polypeptide Fibrillation and Cytotoxicity by the Secretory Chaperones 7B2 and proSAAS
The deposition of fibrillated human islet β-cell peptide islet amyloid polypeptide (hIAPP) into amyloid plaques is characteristic of the pathogenesis of islet cell death during type 2 diabetes. We investigated the effects of the neuroendocrine secretory proteins 7B2 and proSAAS on hIAPP fibrillation...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3845801/ https://ncbi.nlm.nih.gov/pubmed/24042052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.09.006 |
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