A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

Polyglutamine (polyQ) diseases are a class of progressive neurodegenerative disorders characterized by the expression of both expanded CAG RNA and misfolded polyQ protein. We previously reported that the direct interaction between expanded CAG RNA and nucleolar protein nucleolin (NCL) impedes prerib...

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Gepubliceerd in:RNA
Hoofdauteurs: Zhang, Qian, Chen, Zhefan Stephen, An, Ying, Liu, Haizhen, Hou, Yonghui, Li, Wen, Lau, Kwok-Fai, Koon, Alex Chun, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855950/
https://ncbi.nlm.nih.gov/pubmed/29295891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.062703.117
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