A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

Polyglutamine (polyQ) diseases are a class of progressive neurodegenerative disorders characterized by the expression of both expanded CAG RNA and misfolded polyQ protein. We previously reported that the direct interaction between expanded CAG RNA and nucleolar protein nucleolin (NCL) impedes prerib...

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Enregistré dans:
Détails bibliographiques
Publié dans:RNA
Auteurs principaux: Zhang, Qian, Chen, Zhefan Stephen, An, Ying, Liu, Haizhen, Hou, Yonghui, Li, Wen, Lau, Kwok-Fai, Koon, Alex Chun, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855950/
https://ncbi.nlm.nih.gov/pubmed/29295891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.062703.117
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