A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

Polyglutamine (polyQ) diseases are a class of progressive neurodegenerative disorders characterized by the expression of both expanded CAG RNA and misfolded polyQ protein. We previously reported that the direct interaction between expanded CAG RNA and nucleolar protein nucleolin (NCL) impedes prerib...

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Publicado en:RNA
Main Authors: Zhang, Qian, Chen, Zhefan Stephen, An, Ying, Liu, Haizhen, Hou, Yonghui, Li, Wen, Lau, Kwok-Fai, Koon, Alex Chun, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855950/
https://ncbi.nlm.nih.gov/pubmed/29295891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.062703.117
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