CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration

DNA damage plays a central role in the cellular pathogenesis of polyglutamine (polyQ) diseases, including Huntington’s disease (HD). In this study, we showed that the expression of untranslatable expanded CAG RNA per se induced the cellular DNA damage response pathway. By means of RNA sequencing (RN...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Peng, Shaohong, Guo, Pei, Lin, Xiao, An, Ying, Sze, Kong Hung, Lau, Matthew Ho Yan, Chen, Zhefan Stephen, Wang, Qianwen, Li, Wen, Sun, Jacquelyne Ka-Li, Ma, Sum Yi, Chan, Ting-Fung, Lau, Kwok-Fai, Ngo, Jacky Chi Ki, Kwan, Kin Ming, Wong, Chun-Ho, Lam, Sik Lok, Zimmerman, Steven C., Tuccinardi, Tiziano, Zuo, Zhong, Au-Yeung, Ho Yu, Chow, Hei-Man, Chan, Ho Yin Edwin
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126783/
https://ncbi.nlm.nih.gov/pubmed/33947817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022940118
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