CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration

DNA damage plays a central role in the cellular pathogenesis of polyglutamine (polyQ) diseases, including Huntington’s disease (HD). In this study, we showed that the expression of untranslatable expanded CAG RNA per se induced the cellular DNA damage response pathway. By means of RNA sequencing (RN...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Peng, Shaohong, Guo, Pei, Lin, Xiao, An, Ying, Sze, Kong Hung, Lau, Matthew Ho Yan, Chen, Zhefan Stephen, Wang, Qianwen, Li, Wen, Sun, Jacquelyne Ka-Li, Ma, Sum Yi, Chan, Ting-Fung, Lau, Kwok-Fai, Ngo, Jacky Chi Ki, Kwan, Kin Ming, Wong, Chun-Ho, Lam, Sik Lok, Zimmerman, Steven C., Tuccinardi, Tiziano, Zuo, Zhong, Au-Yeung, Ho Yu, Chow, Hei-Man, Chan, Ho Yin Edwin
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2021
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126783/
https://ncbi.nlm.nih.gov/pubmed/33947817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022940118
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