A Herpes Simplex Virus (HSV)-2 Single-Cycle Candidate Vaccine Deleted in Glycoprotein D Protects Male Mice From Lethal Skin Challenge With Clinical Isolates of HSV-1 and HSV-2

Herpes simplex virus (HSV) infections manifest as recurrent oral or genital mucosal lesions, meningoencephalitis, corneal blindness, and perinatal disease. Subunit vaccines have advanced into the clinic without success. None were tested preclinically in male mice. We compared a single-cycle candidat...

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Bibliografiske detaljer
Udgivet i:J Infect Dis
Main Authors: Burn, Clare, Ramsey, Natalie, Garforth, Scott J, Almo, Steven, Jacobs, William R, Herold, Betsy C
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853290/
https://ncbi.nlm.nih.gov/pubmed/29216362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix628
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