Maternal Immunization with a Single-Cycle Herpes Simplex Virus (HSV) Candidate Vaccine, ΔgD-2, Protects Neonatal Mice from Lethal Viral Challenge

BACKGROUND: Perinatal HSV is associated with ~60% mortality if untreated and with substantial morbidity even with appropriate therapy. We recently engineered a single-cycle virus deleted in glycoprotein-D (ΔgD-2) that induces high-titer antibodies (Abs) that are non-neutralizing but activate the Fc...

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Publicado en:Open Forum Infect Dis
Autores principales: Kao, Carol, Burn, Clare, Jacobs, William R, Herold, Betsy C
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632254/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx162.056
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