A Single-Cycle Glycoprotein D Deletion Viral Vaccine Candidate, ΔgD-2, Elicits Polyfunctional Antibodies That Protect against Ocular Herpes Simplex Virus

Herpes simplex virus 1 (HSV-1) is a leading cause of infectious blindness, highlighting the need for effective vaccines. A single-cycle HSV-2 strain with the deletion of glycoprotein D, ΔgD-2, completely protected mice from HSV-1 and HSV-2 skin or vaginal disease and prevented latency following acti...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ramsey, Natalie L. M., Visciano, Maria, Hunte, Richard, Loh, Lip Nam, Burn Aschner, Clare, Jacobs, William R., Herold, Betsy C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307146/
https://ncbi.nlm.nih.gov/pubmed/32295919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00335-20
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