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HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses
Herpes simplex virus (HSV) glycoprotein D (gD) is required for virus entry and cell-to-cell spread, but also binds the host immunomodulatory molecule, HVEM, blocking interactions with its ligands. Natural infection primarily elicits neutralizing antibodies targeting gD, but subunit protein vaccines...
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| Publié dans: | Sci Immunol |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7673108/ https://ncbi.nlm.nih.gov/pubmed/32817296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aax2454 |
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