HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses

Herpes simplex virus (HSV) glycoprotein D (gD) is required for virus entry and cell-to-cell spread, but also binds the host immunomodulatory molecule, HVEM, blocking interactions with its ligands. Natural infection primarily elicits neutralizing antibodies targeting gD, but subunit protein vaccines...

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Publicado en:Sci Immunol
Main Authors: Aschner, Clare Burn, Loh, Lip Nam, Galen, Benjamin, Delwel, Isabel, Jangra, Rohit K., Garforth, Scott J., Chandran, Kartik, Almo, Steven, Jacobs, William R., Ware, Carl F., Herold, Betsy C.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673108/
https://ncbi.nlm.nih.gov/pubmed/32817296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aax2454
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