A Herpes Simplex Virus (HSV)-2 Single-Cycle Candidate Vaccine Deleted in Glycoprotein D Protects Male Mice From Lethal Skin Challenge With Clinical Isolates of HSV-1 and HSV-2

Herpes simplex virus (HSV) infections manifest as recurrent oral or genital mucosal lesions, meningoencephalitis, corneal blindness, and perinatal disease. Subunit vaccines have advanced into the clinic without success. None were tested preclinically in male mice. We compared a single-cycle candidat...

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Podrobná bibliografie
Vydáno v:J Infect Dis
Hlavní autoři: Burn, Clare, Ramsey, Natalie, Garforth, Scott J, Almo, Steven, Jacobs, William R, Herold, Betsy C
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853290/
https://ncbi.nlm.nih.gov/pubmed/29216362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix628
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