Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

There is a substantial need for novel therapeutics to combat the widespread impact caused by Crytosporidium infection. However, there is a lack of knowledge as to which drug pharmacokinetic (PK) characteristics are key to generate an in vivo response, specifically whether systemic drug exposure is c...

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Veröffentlicht in:J Infect Dis
Hauptverfasser: Arnold, Samuel L. M., Choi, Ryan, Hulverson, Matthew A., Schaefer, Deborah A., Vinayak, Sumiti, Vidadala, Rama S. R., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Barrett, Lynn K., Ojo, Kayode K., Fan, Erkang, Maly, Dustin J., Riggs, Michael W., Striepen, Boris, Van Voorhis, Wesley C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Major Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853285/
https://ncbi.nlm.nih.gov/pubmed/28541457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix247
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