Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy

Bumped kinase inhibitors (BKIs) of Cryptosporidium parvum calcium-dependent protein kinase 1 (CpCDPK1) are leading candidates for treatment of cryptosporidiosis-associated diarrhea. Potential cardiotoxicity related to anti–human ether-à-go-go potassium channel (hERG) activity of the first-generation...

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Bibliographic Details
Published in:J Infect Dis
Main Authors: Hulverson, Matthew A., Vinayak, Sumiti, Choi, Ryan, Schaefer, Deborah A., Castellanos-Gonzalez, Alejandro, Vidadala, Rama S. R., Brooks, Carrie F., Herbert, Gillian T., Betzer, Dana P., Whitman, Grant R., Sparks, Hayley N., Arnold, Samuel L. M., Rivas, Kasey L., Barrett, Lynn K., White, A. Clinton, Maly, Dustin J., Riggs, Michael W., Striepen, Boris, Van Voorhis, Wesley C., Ojo, Kayode K.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Major Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853794/
https://ncbi.nlm.nih.gov/pubmed/28329187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix120
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