Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

There is a substantial need for novel therapeutics to combat the widespread impact caused by Crytosporidium infection. However, there is a lack of knowledge as to which drug pharmacokinetic (PK) characteristics are key to generate an in vivo response, specifically whether systemic drug exposure is c...

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Pubblicato in:J Infect Dis
Autori principali: Arnold, Samuel L. M., Choi, Ryan, Hulverson, Matthew A., Schaefer, Deborah A., Vinayak, Sumiti, Vidadala, Rama S. R., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Barrett, Lynn K., Ojo, Kayode K., Fan, Erkang, Maly, Dustin J., Riggs, Michael W., Striepen, Boris, Van Voorhis, Wesley C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Major Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853285/
https://ncbi.nlm.nih.gov/pubmed/28541457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix247
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