Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

There is a substantial need for novel therapeutics to combat the widespread impact caused by Crytosporidium infection. However, there is a lack of knowledge as to which drug pharmacokinetic (PK) characteristics are key to generate an in vivo response, specifically whether systemic drug exposure is c...

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Publicado en:J Infect Dis
Main Authors: Arnold, Samuel L. M., Choi, Ryan, Hulverson, Matthew A., Schaefer, Deborah A., Vinayak, Sumiti, Vidadala, Rama S. R., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Barrett, Lynn K., Ojo, Kayode K., Fan, Erkang, Maly, Dustin J., Riggs, Michael W., Striepen, Boris, Van Voorhis, Wesley C.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Major Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853285/
https://ncbi.nlm.nih.gov/pubmed/28541457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix247
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