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Selectivity determinants of GPCR-G protein binding
The selective coupling of G protein-coupled receptors (GPCRs) to specific G proteins is critical to trigger the appropriate physiological response. However, the determinants of selective binding have remained elusive. Here, we reveal the existence of a selectivity barcode (i.e. patterns of amino aci...
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| Publicat a: | Nature |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5846738/ https://ncbi.nlm.nih.gov/pubmed/28489817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22070 |
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