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Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation
Arrestins regulate signalling of ligand-activated, phosphorylated G protein-coupled receptors (GPCRs). Different patterns of receptor phosphorylations (phosphorylation barcode) can modulate arrestin conformations, resulting in distinct functional outcomes (e.g. desensitization, internalisation, down...
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| Izdano u: | Nat Struct Mol Biol |
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| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6101189/ https://ncbi.nlm.nih.gov/pubmed/29872229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0071-3 |
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