Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation

Arrestins regulate signalling of ligand-activated, phosphorylated G protein-coupled receptors (GPCRs). Different patterns of receptor phosphorylations (phosphorylation barcode) can modulate arrestin conformations, resulting in distinct functional outcomes (e.g. desensitization, internalisation, down...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Sente, Andrija, Peer, Raphael, Srivastava, Ashish, Baidya, Mithu, Lesk, Arthur M., Balaji, Santhanam, Shukla, Arun K., Babu, M. Madan, Flock, Tilman
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101189/
https://ncbi.nlm.nih.gov/pubmed/29872229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0071-3
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