Species differences and mechanism of action of A(3) adenosine receptor allosteric modulators

Activity of the A(3) adenosine receptor (AR) allosteric modulators LUF6000 (2-cyclohexyl-N-(3,4-dichlorophenyl)-1H-imidazo [4,5-c]quinolin-4-amine) and LUF6096 (N-{2-[(3,4-dichlorophenyl)amino]quinolin-4-yl}cyclohexanecarbox-amide) was compared at four A(3)AR species homologs used in preclinical dru...

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Publicat a:Purinergic Signal
Autors principals: Du, Lili, Gao, Zhan-Guo, Paoletta, Silvia, Wan, Tina C., Gizewski, Elizabeth T., Barbour, Samantha, van Veldhoven, Jacobus P. D., IJzerman, Adriaan P., Jacobson, Kenneth A., Auchampach, John A.
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842153/
https://ncbi.nlm.nih.gov/pubmed/29170977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-017-9592-1
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