Structures of human PRC2 with its cofactors AEBP2 and JARID2

Transcriptionally repressive histone H3 lysine 27 methylation by Polycomb repressive complex 2 (PRC2) is essential for cellular differentiation and development. Here we report cryo–electron microscopy structures of human PRC2 in a basal state and two distinct active states while in complex with its...

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Опубликовано в: :Science
Главные авторы: Kasinath, Vignesh, Faini, Marco, Poepsel, Simon, Reif, Dvir, Feng, Xinyu Ashlee, Stjepanovic, Goran, Aebersold, Ruedi, Nogales, Eva
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840869/
https://ncbi.nlm.nih.gov/pubmed/29348366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar5700
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