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Structures of human PRC2 with its cofactors AEBP2 and JARID2
Transcriptionally repressive histone H3 lysine 27 methylation by Polycomb repressive complex 2 (PRC2) is essential for cellular differentiation and development. Here we report cryo–electron microscopy structures of human PRC2 in a basal state and two distinct active states while in complex with its...
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| Pubblicato in: | Science |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5840869/ https://ncbi.nlm.nih.gov/pubmed/29348366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar5700 |
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