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Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes
Epigenetic regulation is mediated by protein complexes that couple recognition of chromatin marks to activity or recruitment of chromatin-modifying enzymes. Polycomb repressive complex 2 (PRC2), a gene silencer that methylates lysine 27 of histone H3, is stimulated upon recognition of its own cataly...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5805599/ https://ncbi.nlm.nih.gov/pubmed/29379173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0023-y |
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