Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer

Drug resistance to approved systemic therapies in estrogen receptor–positive (ER+) breast cancer remains common. We hypothesized that factors present in the human tumor microenvironment (TME) drive drug resistance. Screening of a library of recombinant secreted microenvironmental proteins revealed f...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Med
Prif Awduron: Shee, Kevin, Yang, Wei, Hinds, John W., Hampsch, Riley A., Varn, Frederick S., Traphagen, Nicole A., Patel, Kishan, Cheng, Chao, Jenkins, Nicole P., Kettenbach, Arminja N., Demidenko, Eugene, Owens, Philip, Faber, Anthony C., Golub, Todd R., Straussman, Ravid, Miller, Todd W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2018
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839765/
https://ncbi.nlm.nih.gov/pubmed/29436393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171818
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