Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer

Drug resistance to approved systemic therapies in estrogen receptor–positive (ER+) breast cancer remains common. We hypothesized that factors present in the human tumor microenvironment (TME) drive drug resistance. Screening of a library of recombinant secreted microenvironmental proteins revealed f...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Shee, Kevin, Yang, Wei, Hinds, John W., Hampsch, Riley A., Varn, Frederick S., Traphagen, Nicole A., Patel, Kishan, Cheng, Chao, Jenkins, Nicole P., Kettenbach, Arminja N., Demidenko, Eugene, Owens, Philip, Faber, Anthony C., Golub, Todd R., Straussman, Ravid, Miller, Todd W.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2018
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839765/
https://ncbi.nlm.nih.gov/pubmed/29436393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171818
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