Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER(+) breast cancer

Despite the success of approved systemic therapies for estrogen receptor α (ER)-positive breast cancer, drug resistance remains common. We hypothesized that secreted factors from the human tumor microenvironment could modulate drug resistance. We previously screened a library of 297 recombinant-secr...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Shee, Kevin, Jiang, Amanda, Varn, Frederick S., Liu, Stephanie, Traphagen, Nicole A., Owens, Philip, Ma, Cynthia X., Hoog, Jeremy, Cheng, Chao, Golub, Todd R., Straussman, Ravid, Miller, Todd W.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338642/
https://ncbi.nlm.nih.gov/pubmed/30161001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801241R
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