Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer

Drug resistance to approved systemic therapies in estrogen receptor–positive (ER+) breast cancer remains common. We hypothesized that factors present in the human tumor microenvironment (TME) drive drug resistance. Screening of a library of recombinant secreted microenvironmental proteins revealed f...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Shee, Kevin, Yang, Wei, Hinds, John W., Hampsch, Riley A., Varn, Frederick S., Traphagen, Nicole A., Patel, Kishan, Cheng, Chao, Jenkins, Nicole P., Kettenbach, Arminja N., Demidenko, Eugene, Owens, Philip, Faber, Anthony C., Golub, Todd R., Straussman, Ravid, Miller, Todd W.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839765/
https://ncbi.nlm.nih.gov/pubmed/29436393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171818
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