Autophagy promotes escape from phosphatidylinositol 3-kinase inhibition in estrogen receptor–positive breast cancer

Por Yang, Wei, Hosford, Sarah R., Traphagen, Nicole A., Shee, Kevin, Demidenko, Eugene, Liu, Stephanie, Miller, Todd W.
Publicado no FASEB J (2018)

Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer

Por Yang, Wei, Schwartz, Gary N., Marotti, Jonathan D., Chen, Vivian, Traphagen, Nicole A., Gui, Jiang, Miller, Todd W.
Publicado no Oncotarget (2018)

Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer

Por Hosford, Sarah R., Shee, Kevin, Wells, Jason D., Traphagen, Nicole A., Fields, Jennifer L., Hampsch, Riley A., Kettenbach, Arminja N., Demidenko, Eugene, Miller, Todd W.
Publicado no Mol Oncol (2019)

Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER(+) breast cancer

Por Shee, Kevin, Jiang, Amanda, Varn, Frederick S., Liu, Stephanie, Traphagen, Nicole A., Owens, Philip, Ma, Cynthia X., Hoog, Jeremy, Cheng, Chao, Golub, Todd R., Straussman, Ravid, Miller, Todd W.
Publicado no FASEB J (2019)

Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells

Por Allaway, Robert J., Wood, Matthew D., Downey, Sondra L., Bouley, Stephanie J., Traphagen, Nicole A., Wells, Jason D., Batra, Jaya, Melancon, Sir Norman, Ringelberg, Carol, Seibel, William, Ratner, Nancy, Sanchez, Yolanda
Publicado no Oncotarget (2017)

Tumor pharmacokinetics and pharmacodynamics of the CDK4/6 inhibitor ribociclib in patients with recurrent glioblastoma

Por Miller, Todd W., Traphagen, Nicole A., Li, Jing, Lewis, Lionel D., Lopes, Beatriz, Asthagiri, Ashok, Loomba, Johanna, De Jong, Jenny, Schiff, David, Patel, Sohil H., Purow, Benjamin W., Fadul, Camilo E.
Publicado no J Neurooncol (2019)

Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells

Por Lupien, Leslie E., Bloch, Katarzyna, Dehairs, Jonas, Traphagen, Nicole A., Feng, William W., Davis, Wilson L., Dennis, Thea, Swinnen, Johannes V., Wells, Wendy A., Smits, Nicole C., Kuemmerle, Nancy B., Miller, Todd W., Kinlaw, William B.
Publicado no J Lipid Res (2020)

Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer

Por Shee, Kevin, Yang, Wei, Hinds, John W., Hampsch, Riley A., Varn, Frederick S., Traphagen, Nicole A., Patel, Kishan, Cheng, Chao, Jenkins, Nicole P., Kettenbach, Arminja N., Demidenko, Eugene, Owens, Philip, Faber, Anthony C., Golub, Todd R., Straussman, Ravid, Miller, Todd W.
Publicado no J Exp Med (2018)

A transcriptionally-definable subgroup of triple-negative breast and ovarian cancer samples shows sensitivity to HSP90 inhibition

Por Shee, Kevin, Wells, Jason D., Ung, Matthew, Hampsch, Riley A., Traphagen, Nicole A., Yang, Wei, Liu, Stephanie, Zeldenrust, Megan A., Wang, Liewei, Kalari, Krishna R., Yu, Jia, Boughey, Judy C., Demidenko, Eugene, Kettenbach, Arminja N., Cheng, Chao, Goetz, Matthew P., Miller, Todd W.
Publicado no Clin Cancer Res (2019)

AMPK activation by metformin promotes survival of dormant ER+ breast cancer cells

Por Hampsch, Riley A., Wells, Jason D., Traphagen, Nicole A., McCleery, Charlotte F., Fields, Jennifer L., Shee, Kevin, Dillon, Lloye M., Pooler, Darcy B., Lewis, Lionel D., Demidenko, Eugene, Huang, Yina H., Marotti, Jonathan D., Goen, Abigail E., Kinlaw, William B., Miller, Todd W.
Publicado no Clin Cancer Res (2020)